API

DOXYCYCLINE

Drug classification

Antibiotics (tetracycline antibiotic)

Dosage form

CAPSULE;ORAL

API strength per dosage

EQ 150MG BASE

Dose

Adults: 100-200 mg daily in 1-2 divided doses. Pediatrics (>8 years): 2-4 mg/kg/day in 1-2 divided doses, max 200 mg/day. Reduce dose in severe renal impairment. Not recommended for children under 8 years, pregnant or breastfeeding women due to risk of tooth discoloration and bone growth effects.

Mechanism of action

Doxycycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, specifically blocking the attachment of aminoacyl-tRNA to the mRNA-ribosome complex. This action prevents the addition of amino acids to the growing peptide chain, effectively halting bacterial growth.

Indications

Side effects

Pregnancy category

Precautions

Contraindications