API

VIOMYCIN SULFATE

Drug classification

Antibiotics (aminoglycoside antibiotic)

Dosage form

INJECTABLE;INJECTION

API strength per dosage

EQ 1GM BASE/VIAL

Dose

Viocin sulfate (viomycin sulfate) dosage: Adults and children—15 mg/kg/day IV or IM, divided into 2 or 3 doses, maximum 1 g/day. Adjust dose for renal impairment. Not recommended for routine use due to toxicity; consider alternatives first.

Mechanism of action

Viocin sulfate (viomycin sulfate) binds to the 30S subunit of bacterial ribosomes, inhibiting protein synthesis by disrupting the initiation complex and causing misreading of mRNA, leading to bactericidal effects against primarily tubercle bacilli.

Indications

Treatment of pulmonary tuberculosis, particularly when resistant to other antitubercular drugs, adjunct therapy in multidrug-resistant tuberculosis (MDR-TB).

Side effects

Pregnancy category

Precautions

Monitor renal function, auditory function, and vestibular function regularly, avoid concurrent use with other nephrotoxic or ototoxic drugs, adjust dosage in renal impairment, use cautiously in patients with neuromuscular disorders, perform regular blood tests to monitor for leukopenia and thrombocytopenia, ensure adequate hydration during treatment.

Contraindications