API

Thiocolchicoside (4mg) + Diclofenac (50mg)

Drug classification

Skeletal muscle relaxant (thiocolchicoside) and nonsteroidal anti-inflammatory drug—NSAID (diclofenac).

Dosage form

Thioact D 4 Capsule is available as an oral capsule formulation.

API strength per dosage

Dose

Thioact D 4 Capsule typically contains thiocolchicoside 4 mg and diclofenac 50 mg, used in adults for short-term relief of painful muscle spasms. Not recommended for children, pregnant, or breastfeeding women. Use with caution in renal or hepatic impairment; dose adjustment or avoidance may be necessary. Always follow prescribing information and consult a healthcare professional.

Mechanism of action

Thiocolchicoside acts as a selective GABA-A and glycine receptor agonist, inhibiting spinal reflexes and producing muscle relaxation. Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis, which decreases inflammation and pain. Together, they provide muscle relaxation and anti-inflammatory analgesia.

Indications

Pain due to muscle spasm

Side effects

Nausea Vomiting Diarrhea Heartburn Stomach pain epigastric pain Loss of appetite

Pregnancy category

Thiocolchicoside and diclofenac are generally not recommended in pregnancy due to potential fetal risks; use only if clearly needed and prescribed by a physician.

Precautions

History of hypersensitivity, gastrointestinal bleeding or ulcer risk, renal or hepatic impairment, seizure disorders, pregnancy and lactation, elderly patients, concurrent anticoagulant or nephrotoxic drugs, monitor for GI symptoms, liver and renal function, CNS effects, allergic reactions, avoid alcohol, use lowest effective dose.

Contraindications

Hypersensitivity to thiocolchicoside, colchicoside derivatives, diclofenac, NSAIDs; history of asthma, urticaria, or allergic reactions after NSAIDs; active gastrointestinal bleeding or ulcer; severe hepatic, renal, or heart failure; pregnancy; lactation.