API

Sacubitril (24mg) + Valsartan (26mg)

Drug classification

Sacubitril: Neprilysin inhibitor; Valsartan: Angiotensin receptor blocker; ARNI.

Dosage form

Film-coated tablet

API strength per dosage

Sacubitril 24 mg, Valsartan 26 mg per tablet.

Dose

Adults: 50 mg (sacubitril 24 mg/valsartan 26 mg) twice daily, titrated to 200 mg (sacubitril 97 mg/valsartan 103 mg) twice daily as tolerated. Not recommended in pediatric patients. Dose adjustment required in severe renal or hepatic impairment; contraindicated in pregnancy.

Mechanism of action

Inhibits neprilysin (neutral endopeptidase, EC 3.4.24.11), increasing natriuretic peptides, and antagonizes angiotensin II type 1 (AT1) receptors, blocking angiotensin II-mediated vasoconstriction and aldosterone release, resulting in vasodilation, natriuresis, and reduced cardiac remodeling.

Indications

Treatment of Heart failure

Side effects

Dizziness Increased potassium level in blood Fatigue Hypotension low blood pressure

Pregnancy category

Precautions

Contraindications