API

Thiocolchicoside (4mg) + Diclofenac (50mg)

Drug classification

Skeletal muscle relaxant (thiocolchicoside) and nonsteroidal anti-inflammatory drug—NSAID (diclofenac).

Dosage form

Thioquest D 4 Capsule is an oral capsule formulation.

API strength per dosage

Dose

Thioquest D 4 Capsule typically contains thiocolchicoside 4 mg and diclofenac 50 mg. Standard adult dosing is one capsule twice daily after meals. Use in children, and patients with severe renal or hepatic impairment is not recommended due to safety concerns. Always follow prescribing information and consult a healthcare professional for individual adjustments.

Mechanism of action

Thiocolchicoside acts as a selective GABA-A and glycine receptor agonist, inhibiting spinal motor neuron excitability and producing muscle relaxation. Diclofenac inhibits cyclooxygenase (COX-1 and COX-2) enzymes, reducing prostaglandin synthesis, which decreases inflammation and pain. Together, they provide muscle relaxation and anti-inflammatory analgesia.

Indications

Pain due to muscle spasm

Side effects

Nausea Vomiting Diarrhea Heartburn Stomach pain epigastric pain Loss of appetite

Pregnancy category

Thiocolchicoside and diclofenac are generally not recommended in pregnancy due to potential fetal risks; use only if clearly needed and prescribed by a physician.

Precautions

History of hypersensitivity, gastrointestinal bleeding or ulcer risk, renal or hepatic impairment, seizure disorders, pregnancy and lactation, avoid in children, monitor for allergic reactions, gastrointestinal symptoms, renal and liver function, neurological symptoms, avoid alcohol, caution with other NSAIDs or muscle relaxants.

Contraindications

Hypersensitivity to thiocolchicoside, colchicoside derivatives, diclofenac, NSAIDs; history of asthma, urticaria, or allergic reactions after NSAIDs; active peptic ulcer, gastrointestinal bleeding, severe hepatic, renal, or cardiac impairment, pregnancy, lactation.