API

Chlorpheniramine Maleate (2mg) + Paracetamol (125mg) + Phenylephrine (2.5mg)

Drug classification

Antihistamine (first-generation), analgesic/antipyretic, and sympathomimetic (decongestant) combination.

Dosage form

Oral suspension containing chlorpheniramine, paracetamol, and phenylephrine.

API strength per dosage

Dose

Zukamin Cold Suspension is typically dosed in children based on age and weight; adult dosing is not standard for this formulation. Use caution in hepatic or renal impairment due to paracetamol. Avoid exceeding recommended paracetamol daily limits. Not for children under 2 years unless directed by a physician. Always follow local prescribing guidelines.

Mechanism of action

Chlorpheniramine maleate blocks H1 histamine receptors, reducing allergic symptoms; paracetamol inhibits central prostaglandin synthesis via COX enzymes, lowering fever and pain; phenylephrine is an alpha-1 adrenergic agonist, causing vasoconstriction in nasal mucosa, decreasing congestion.

Indications

Treatment of Common cold

Side effects

Diarrhea Rash Nausea Headache Insomnia difficulty in sleeping Dizziness Tachycardia Palpitations Fear Anxiety Restlessness Tremors Weakness Discomfort when urinating Hallucination Convulsion

Pregnancy category

Safety in pregnancy is not established; use only if clearly needed and benefits outweigh potential risks. Consult a healthcare provider before use.

Precautions

Avoid in children under recommended age, monitor for drowsiness, caution in hypertension, heart disease, diabetes, glaucoma, urinary retention, hepatic or renal impairment, avoid concurrent use with other antihistamines or decongestants, monitor for allergic reactions, do not exceed recommended dose, assess for symptom improvement.

Contraindications

Hypersensitivity to any component, severe hypertension, severe coronary artery disease, concurrent or recent (within 14 days) MAOI use, severe hepatic impairment, narrow-angle glaucoma, urinary retention, prostatic hypertrophy, severe renal impairment.