API

Phenylephrine (0.10% w/w) + Beclometasone (0.025% w/w) + Lidocaine (2.50% w/w)

Drug classification

Phenylephrine: Vasoconstrictor; Beclometasone: Corticosteroid; Lidocaine: Local anesthetic. Combination: Antihemorrhoidal.

Dosage form

API strength per dosage

Dose

Mechanism of action

Phenylephrine is an α1-adrenergic receptor agonist causing local vasoconstriction; beclometasone binds glucocorticoid receptors, inhibiting NF-κB-mediated pro-inflammatory gene transcription; lidocaine blocks voltage-gated sodium channels (Nav1.7, Nav1.8), inhibiting neuronal depolarization and nociceptive signal transmission.

Indications

Treatment of Piles

Side effects

Application site reactions burning irritation itching and redness

Pregnancy category

Precautions

Contraindications