API

Betahistine (16mg)

Drug classification

Histamine analogues (histamine H1 agonist and H3 antagonist)

Dosage form

Tablet

API strength per dosage

16 mg

Dose

Adults: 16 mg orally three times daily. Pediatric use: Safety and efficacy not established. Use with caution in hepatic or renal impairment; dose adjustment may be necessary. Not recommended during pregnancy or lactation unless clearly needed.

Mechanism of action

Acts as a weak agonist at histamine H1 receptors and a strong antagonist at histamine H3 receptors in the central and vestibular systems, enhancing histaminergic neurotransmission, increasing vestibular blood flow, and reducing endolymphatic pressure, thereby alleviating vertigo symptoms.

Indications

Treatment of Meniere's disease

Side effects

Headache Indigestion Nausea Stomach pain Bloating

Pregnancy category

Precautions

Contraindications

Pheochromocytoma, hypersensitivity to betahistine or excipients, active peptic ulcer.