API

Glibenclamide (5mg) + Metformin (500mg)

Drug classification

Glibenclamide: Antidiabetic (sulfonylurea), Metformin: Antidiabetic (biguanide). Combination: Oral antidiabetic agents.

Dosage form

Tablet

API strength per dosage

Glibenclamide 5 mg, Metformin 500 mg per Duotrol Tablet.

Dose

Adults: Initiate with one tablet twice daily, adjust based on glycemic control. Maximum: 4 tablets daily. Pediatrics: Not recommended. Special populations: Use cautiously in renal impairment; contraindicated in severe renal or hepatic dysfunction. Adjust dose in elderly due to potential for renal function decline.

Mechanism of action

Indications

Treatment of Type 2 diabetes mellitus

Side effects

Nausea Vomiting Diarrhea Flatulence

Pregnancy category

Precautions

Monitor blood glucose levels regularly, avoid in severe renal or hepatic impairment, contraindicated in diabetic ketoacidosis, cautious use in elderly, monitor for signs of lactic acidosis, adjust dose in renal impairment, avoid excessive alcohol consumption, not recommended during pregnancy and breastfeeding, assess for allergic reactions to components.

Contraindications