API

Ambroxol (7.5mg) + Guaifenesin (12.5mg) + Terbutaline (0.25mg)

Drug classification

Expectorant and bronchodilator combination; mucolytic (Ambroxol), expectorant (Guaifenesin), beta-2 agonist (Terbutaline).

Dosage form

Oral drops for pediatric use.

API strength per dosage

Dose

Asthakind-P Drops are typically used in children; dosing is based on age and weight, as per physician guidance. Not recommended for adults. Use with caution in renal or hepatic impairment; dose adjustment may be necessary. Always follow prescribing information and consult a healthcare professional for individualized dosing. Avoid exceeding recommended pediatric doses.

Mechanism of action

Ambroxol enhances mucociliary clearance by stimulating surfactant production and lysosomal activity in respiratory tract epithelial cells. Guaifenesin acts as an expectorant, reducing mucus viscosity. Terbutaline is a selective β2-adrenergic receptor agonist, relaxing bronchial smooth muscle and causing bronchodilation, improving airflow and facilitating mucus clearance.

Indications

Treatment of Cough with mucus

Side effects

Excessive salivation Fatigue Paresthesia tingling or pricking sensation Stomach discomfort Arrhythmia irregular heartbeats Nausea Vomiting Diarrhea Dizziness Headache Rash Tremors Increased heart rate Indigestion Bloating Upper abdominal pain Urticaria Itching Sweating Changes in serum aminotransferase levels

Pregnancy category

Safety in pregnancy is not well established; use only if potential benefits justify potential risks. Consult a healthcare provider before use during pregnancy.

Precautions

Monitor for hypersensitivity, paradoxical bronchospasm, cardiovascular effects (tachycardia, palpitations), CNS stimulation, gastrointestinal upset, use cautiously in patients with cardiac disease, hypertension, diabetes, hyperthyroidism, peptic ulcer, renal/hepatic impairment; assess cough type, monitor respiratory status, avoid concurrent use with other adrenergics.

Contraindications

Hypersensitivity to ambroxol, guaifenesin, terbutaline, or excipients, severe hypertension, significant cardiac arrhythmias, hyperthyroidism, peptic ulcer, active gastric ulceration, severe hepatic or renal impairment, history of convulsive disorders.