API

Glimepiride (2mg) + Metformin (500mg)

Drug classification

Glimepiride: Antidiabetic (sulfonylurea), Metformin: Antidiabetic (biguanide), Oral antidiabetic combination.

Dosage form

API strength per dosage

Dose

Adults: One tablet once daily with breakfast or first main meal. Dose may be adjusted based on glycemic response. Not recommended for pediatric use. Use with caution in elderly or renal/hepatic impairment; assess renal function before initiation and regularly thereafter. Contraindicated in severe renal or hepatic dysfunction.

Mechanism of action

Indications

Treatment of Type 2 diabetes mellitus

Side effects

Hypoglycemia low blood glucose level Headache Nausea Diarrhea Flatulence

Pregnancy category

Category C

Precautions

Contraindications

Hypersensitivity to glimepiride or metformin, type 1 diabetes, diabetic ketoacidosis, severe renal impairment, acute or chronic metabolic acidosis, severe hepatic impairment, pregnancy, lactation, acute alcohol intoxication.