API

Ethinyl Estradiol (0.05mg) + Levonorgestrel (0.25mg)

Drug classification

Combined oral contraceptive; estrogen (ethinyl estradiol) and progestin (levonorgestrel) subclass.

Dosage form

Film-coated oral tablet containing ethinyl estradiol and levonorgestrel.

API strength per dosage

Dose

Florina G is typically taken as one tablet daily for 21 consecutive days, followed by a 7-day tablet-free interval. Not recommended before menarche. Use with caution or avoid in severe hepatic impairment; contraindicated in active liver disease. No specific dose adjustment for renal impairment, but caution is advised. Always follow prescribing information.

Mechanism of action

Florina G combines ethinyl estradiol, which suppresses FSH via estrogen receptors, and levonorgestrel, which inhibits LH via progesterone receptors in the hypothalamus and pituitary. This prevents ovulation, thickens cervical mucus (impeding sperm), and alters endometrial lining, reducing the likelihood of implantation.

Indications

Contraception

Side effects

Nausea Headache Breast pain Abdominal pain Weight gain Depression

Pregnancy category

Florina G is contraindicated in pregnancy; discontinue if pregnancy is confirmed, as combined oral contraceptives offer no benefit and may pose risks to the fetus.

Precautions

History of thromboembolic disorders, hypertension, migraine, smoking (especially age >35), liver disease, diabetes, breast cancer, undiagnosed vaginal bleeding, regular blood pressure monitoring, assess for signs of thrombosis, monitor liver function, counsel on missed doses, drug interactions, periodic follow-up.

Contraindications

Known or suspected pregnancy, active or history of thromboembolic disorders, cerebrovascular or coronary artery disease, hormone-sensitive malignancies, undiagnosed vaginal bleeding, severe liver disease, hepatic tumors, hypersensitivity to components.