API

Doxylamine (10mg) + Vitamin B6 (Pyridoxine) (10mg)

Drug classification

Antihistamine (ethanolamine class) and vitamin; antiemetic combination for nausea and vomiting.

Dosage form

Goodmorn Tablet is an oral tablet containing doxylamine and pyridoxine.

API strength per dosage

Dose

Goodmorn Tablet is typically used for nausea and vomiting in pregnancy. Standard adult dosing is one tablet at bedtime; if needed, increase to one tablet morning and afternoon. Not recommended for children. Use caution in renal or hepatic impairment; dose adjustments may be necessary. Always follow local guidelines and consult a healthcare professional before use.

Mechanism of action

Doxylamine, an H1 histamine receptor antagonist, reduces nausea by blocking histaminergic signaling in the vomiting center. Pyridoxine (vitamin B6) acts as a coenzyme in neurotransmitter synthesis, modulating central nervous system pathways involved in nausea and vomiting. Together, they decrease the frequency and severity of nausea and vomiting in pregnancy.

Indications

Treatment of Nausea and vomiting in pregnancy

Side effects

Dryness in mouth Constipation Lightheadedness Drowsiness

Pregnancy category

Doxylamine and pyridoxine are commonly used for nausea and vomiting in pregnancy; considered safe when used as directed, but consult a healthcare provider.

Precautions

Caution in patients with asthma, glaucoma, urinary retention, prostatic hypertrophy, or severe liver impairment, may cause drowsiness—avoid driving or alcohol, monitor for anticholinergic effects, use in pregnancy only if clearly needed, monitor for allergic reactions, avoid concomitant CNS depressants.

Contraindications

Hypersensitivity to doxylamine, pyridoxine, or any tablet component, concurrent use of monoamine oxidase inhibitors (MAOIs), severe liver impairment, narrow-angle glaucoma, urinary retention, acute asthma attacks.