API

Meropenem (1000mg)

Drug classification

Dosage form

Injection (powder for solution), 1000 mg per vial.

API strength per dosage

Dose

Adults: 500 mg to 1 g every 8 hours. Pediatrics (>3 months): 10-40 mg/kg every 8 hours. Renal impairment: Adjust dose based on creatinine clearance. No specific adjustments for hepatic impairment or elderly. Consult specific guidelines for dosing in neonates and for severe infections.

Mechanism of action

Indications

Severe bacterial infections

Side effects

Rash Headache Vomiting Nausea Itching Diarrhea Injection site inflammation Anemia low number of red blood cells Sepsis Constipation Apnea absence of breathing Shock

Pregnancy category

Precautions

Contraindications

Hypersensitivity to meropenem or other carbapenems, severe hypersensitivity (e.g., anaphylactic reactions) to beta-lactams (penicillins, cephalosporins), meningitis in neonates and infants due to possible drug precipitation in CSF.