API

Sumatriptan (85mg) + Naproxen (500mg)

Drug classification

Sumatriptan: Antimigraine (triptan); Naproxen: NSAID; Combination: Antimigraine therapy.

Dosage form

Film-coated tablet

API strength per dosage

Sumatriptan 85 mg, Naproxen 500 mg per tablet.

Dose

Adults: One tablet (sumatriptan 85 mg + naproxen 500 mg) taken orally at migraine onset; may repeat after 2 hours if needed, maximum 2 tablets in 24 hours. Safety and efficacy not established in pediatrics or patients with severe hepatic or renal impairment; use is not recommended in these populations.

Mechanism of action

Indications

Treatment of Migraine

Side effects

Nausea Dizziness Heartburn Chest discomfort Dryness in mouth Weakness Muscle stiffness Drowsiness Numbness of extremity Arrhythmia irregular heartbeats Feeling hot

Pregnancy category

Precautions

Cardiovascular disease, uncontrolled hypertension, history of stroke or TIA, severe hepatic or renal impairment, peptic ulcer disease, gastrointestinal bleeding, pregnancy, breastfeeding, concomitant use of SSRIs/SNRIs/MAOIs, risk of serotonin syndrome, hypersensitivity to sumatriptan, naproxen, or NSAIDs, asthma, elderly patients.

Contraindications