API

Metronidazole (400mg)

Drug classification

Dosage form

Aristogyl 400 Tablet is available in tablet form.

API strength per dosage

Aristogyl 400 Tablet contains 400 mg of Metronidazole per tablet.

Dose

Adults: 400 mg three times daily. Pediatrics: 7.5 mg/kg every 8 hours. Special populations: In renal impairment, adjust dose based on creatinine clearance. For hepatic impairment, consider dose reduction. Always consult specific guidelines for detailed dosing in relation to condition and severity.

Mechanism of action

Indications

Treatment of Bacterial infectionsTreatment of Parasitic infections

Side effects

Headache Dryness in mouth Nausea Metallic taste

Pregnancy category

Precautions

Avoid alcohol during treatment and for at least 48 hours after, monitor for signs of neurotoxicity, use cautiously in liver impairment, consider dose adjustment in renal impairment, potential risk of candidiasis, may interfere with AST, ALT, LDH, triglycerides, glucose tests, avoid in first trimester of pregnancy unless necessary.

Contraindications

Hypersensitivity to metronidazole or nitroimidazoles, first trimester of pregnancy, active central nervous system disease, severe hepatic impairment, blood dyscrasias, concurrent disulfiram use, alcohol consumption.