API

Alpha Ketoanalogue (200mg)

Drug classification

Alpha Ketoanalogue: Nutritional supplement (essential amino acid analogue).

Dosage form

Tablet

API strength per dosage

200 mg per tablet

Dose

Adults: 1 tablet per 5 kg body weight daily in divided doses with meals. Pediatric dosing and use in pregnancy or lactation are not established; consult specialist. Dose adjustment may be required in hepatic impairment.

Mechanism of action

Alpha-ketoanalogues serve as nitrogen-free substrates for transamination, accepting amino groups from endogenous amino acids via aminotransferase enzymes, thereby reducing ammonia formation and urea generation, while providing precursors for essential amino acid synthesis, ultimately minimizing nitrogenous waste accumulation in chronic kidney disease without directly targeting receptors or enzymes.

Indications

Treatment of Chronic kidney disease

Side effects

Increased calcium level in blood

Pregnancy category

Precautions

Contraindications