API

Furosemide (10mg/ml)

Drug classification

Diuretics (loop diuretic)

Dosage form

Solution for injection

API strength per dosage

10 mg per 1 ml

Dose

Adults: 20–40 mg IV, may repeat or increase by 20 mg every 2 hours as needed. Pediatrics: 0.5–1 mg/kg IV, may increase by 1 mg/kg every 2 hours (max 6 mg/kg). Elderly: Use lowest effective dose; monitor closely for dehydration and electrolyte imbalance.

Mechanism of action

Inhibits the Na⁺-K⁺-2Cl⁻ cotransporter (NKCC2, SLC12A1) in the thick ascending limb of the loop of Henle, reducing reabsorption of sodium, potassium, and chloride, leading to increased urinary excretion of water, sodium, chloride, potassium, calcium, and magnesium, resulting in diuresis.

Indications

Treatment of Hypertensive emergencyTreatment of Edema

Side effects

Dizziness Weakness Dehydration Decreased potassium level in blood Increased blood uric acid Decreased magnesium level in blood Increased thirst

Pregnancy category

Category C

Precautions

Monitor for electrolyte imbalances, assess renal function, avoid rapid IV administration, monitor blood pressure, use caution in hepatic impairment, risk of ototoxicity, monitor for dehydration, adjust dose in elderly, caution in patients with diabetes, avoid in anuria, monitor for hypersensitivity reactions.

Contraindications

Anuria, severe hypokalemia, severe hyponatremia, hepatic coma, pre-existing electrolyte depletion, hypersensitivity to furosemide or sulfonamides.