API

Disodium Hydrogen Citrate (1.37gm/5ml)

Drug classification

Dosage form

Oral syrup

API strength per dosage

Dose

Adults: 15–30 ml diluted with water, 2–3 times daily. Children: 5–10 ml diluted with water, 2–3 times daily. Dose adjustment may be required in renal impairment; use with caution. Always administer after meals and under medical supervision.

Mechanism of action

Disodium hydrogen citrate dissociates to citrate ions, which are metabolized to bicarbonate in the liver, increasing systemic and urinary pH by buffering hydrogen ions, thereby alkalinizing urine; it does not act via receptors or enzymes but alters acid-base balance through metabolic conversion and renal excretion pathways.

Indications

Treatment of GoutTreatment of Kidney stone

Side effects

Stomach pain Tiredness Diarrhea Nausea Vomiting Frequent urge to urinate

Pregnancy category

Category B

Precautions

Contraindications

Severe renal impairment, metabolic or respiratory alkalosis, sodium-restricted diets, hypersensitivity to disodium hydrogen citrate, acute urinary tract obstruction.