API

Atropine (1% w/v) + Chloramphenicol (0.5% w/v) + Dexamethasone (0.1% w/v)

Drug classification

Atropine: Anticholinergic; Chloramphenicol: Antibiotic; Dexamethasone: Corticosteroid; Combination: Anti-infective and anti-inflammatory.

Dosage form

API strength per dosage

Dose

Mechanism of action

Atropine antagonizes muscarinic acetylcholine receptors (primarily M3) in the iris sphincter and ciliary muscle, causing mydriasis and cycloplegia; chloramphenicol inhibits bacterial 50S ribosomal subunit, blocking protein synthesis; dexamethasone binds cytosolic glucocorticoid receptors, modulating gene transcription to suppress inflammatory cytokine production.

Indications

Treatment of Uveitis

Side effects

Application site reactions burning irritation itching and redness

Pregnancy category

Precautions

Contraindications