API

Acebrophylline (100mg) + Acetylcysteine (600mg)

Drug classification

Dosage form

API strength per dosage

Dose

Adults: One tablet of AB-Flo-N (Acebrophylline 100mg + Acetylcysteine 600mg) twice daily. Pediatric use and specific recommendations for special populations are not established; consult a healthcare provider for appropriate dosing in these groups.

Mechanism of action

Acebrophylline, a xanthine derivative, inhibits phosphodiesterase, reducing intracellular cAMP degradation, and blocks adenosine receptors, leading to bronchodilation. Acetylcysteine cleaves disulfide bonds in mucoproteins, decreasing mucus viscosity. Together, they enhance mucociliary clearance and improve respiratory function.

Indications

Treatment of Chronic obstructive pulmonary disease (COPD)

Side effects

Vomiting Heartburn Stomach pain Upset stomach Rash Hives Itching Breathing problems Nasal inflammation Increased white blood cell count

Pregnancy category

Precautions

Contraindications