API

Atropine (0.01% w/v)

Drug classification

Anticholinergic agent; specifically, a muscarinic receptor antagonist (antimuscarinic).

Dosage form

Sterile ophthalmic solution for topical administration to the eye.

API strength per dosage

Dose

Myotry Pediatric Eye Drop (Atropine 0.01% w/v) is typically used in children for myopia control, with dosing as directed by an ophthalmologist, often one drop in each eye once daily. Safety and efficacy in adults, or in renal or hepatic impairment, are not established; use only as prescribed and under specialist supervision.

Mechanism of action

Atropine 0.01% is a non-selective muscarinic acetylcholine receptor antagonist. By blocking M1–M5 receptors in the iris sphincter and ciliary body, it inhibits parasympathetic stimulation, causing pupil dilation (mydriasis) and paralysis of accommodation (cycloplegia), and reduces excessive eye growth, thereby slowing myopia progression in children.

Indications

Treatment of Myopia

Side effects

Stinging sensation

Pregnancy category

Safety of atropine ophthalmic use in pregnancy is not well established; use only if potential benefits justify potential risks to the fetus.

Precautions

Contraindicated in hypersensitivity to atropine, use caution in children with Down syndrome, spastic paralysis, or brain damage, monitor for allergic reactions, photophobia, blurred vision, increased intraocular pressure, systemic anticholinergic effects, avoid contact lenses, supervise pediatric use, regular ophthalmic follow-up recommended.

Contraindications

Hypersensitivity to atropine or any component, primary glaucoma or predisposition to angle-closure glaucoma, untreated narrow-angle glaucoma, and known hypersensitivity to belladonna alkaloids.