API

Clozapine (12.5mg)

Drug classification

Antipsychotics (atypical antipsychotic)

Dosage form

Orally disintegrating tablet

API strength per dosage

12.5 mg

Dose

Mechanism of action

Antagonizes dopamine D2, D4, and serotonin 5-HT2A receptors, with additional antagonism at adrenergic α1, histamine H1, and muscarinic M1 receptors, reducing dopaminergic and serotonergic neurotransmission in the mesolimbic pathway, thereby alleviating psychotic symptoms and modulating mood, cognition, and behavior.

Indications

Schizophrenia

Side effects

Dizziness Fainting Constipation Fever Weight gain Decreased white blood cell count Extrapyramidal symptoms Increased liver enzymes Drowsiness Seizure Increased white blood cell count eosinophils Anticholinergic effects Tachycardia Excessive salivation

Pregnancy category

Precautions

Contraindications