API

Doxylamine (10mg) + Vitamin B6 (Pyridoxine) (10mg)

Drug classification

Doxylamine: Antihistamine; Pyridoxine: Vitamin B6; Antiemetic combination.

Dosage form

Tablet

API strength per dosage

Doxylamine 10 mg, Pyridoxine (Vitamin B6) 10 mg.

Dose

Adults: 1 tablet orally at bedtime; if needed, increase to 1 tablet in the morning and 1 at bedtime. Maximum: 2 tablets daily. Not recommended for children. Use with caution in elderly and hepatic impairment; dose adjustment may be necessary. Avoid in severe renal or hepatic dysfunction.

Mechanism of action

Indications

Treatment of Nausea and vomiting in pregnancy

Side effects

Dryness in mouth Constipation Lightheadedness Drowsiness

Pregnancy category

Category A

Precautions

Contraindications

Hypersensitivity to doxylamine, pyridoxine, or excipients, concurrent use of monoamine oxidase inhibitors (MAOIs), severe liver impairment, narrow-angle glaucoma, urinary retention, acute asthma attacks.