API

Sodium Hyaluronate (1mg/ml)

Drug classification

Ophthalmic lubricant; specific subclass: artificial tear (ocular surface lubricant).

Dosage form

Sterile ophthalmic solution for topical administration to the eye.

API strength per dosage

Dose

Sodium hyaluronate 1mg/ml eye drops are typically instilled 1–2 drops into the affected eye(s) as needed. Dosing frequency may vary based on symptom severity. No specific adult, paediatric, renal, or hepatic dose adjustments are generally required. Use under medical supervision; avoid touching the dropper tip to any surface to prevent contamination.

Mechanism of action

Sodium hyaluronate acts as a viscoelastic polymer, binding water molecules on the ocular surface. It stabilizes the tear film and prolongs tear retention by adhering to the corneal and conjunctival epithelium, reducing evaporation and friction, thereby relieving dryness and irritation without direct pharmacological receptor targets.

Indications

Treatment of Dry eyes

Side effects

Limited data available

Pregnancy category

Safety of sodium hyaluronate ophthalmic use in pregnancy is not well established; use only if potential benefit justifies potential risk to the fetus.

Precautions

Avoid contamination of dropper tip, do not use if solution changes color or becomes cloudy, remove contact lenses before use, monitor for allergic reactions, use with caution in patients with hypersensitivity to ingredients, report persistent eye irritation or visual changes, store as directed, discard after recommended period.

Contraindications

Hypersensitivity to sodium hyaluronate or any component of the formulation, active ocular infection, do not use with soft contact lenses in place, avoid use if solution changes color or becomes cloudy.