API

Losartan (50mg) + Amlodipine (5mg)

Drug classification

Antihypertensive; Angiotensin II receptor blocker (losartan) and calcium channel blocker (amlodipine).

Dosage form

Film-coated oral tablet containing losartan 50mg and amlodipine 5mg.

API strength per dosage

Dose

Nusar-AM 5 Tablet contains losartan 50 mg and amlodipine 5 mg, typically taken once daily for hypertension in adults. Dose adjustments may be needed in elderly, hepatic impairment, or volume-depleted patients. Not routinely recommended in children. Use caution and consider lower starting doses in hepatic impairment; monitor renal function regularly. Always individualize therapy per clinical response.

Mechanism of action

Losartan selectively blocks angiotensin II type 1 (AT1) receptors, inhibiting vasoconstriction and aldosterone secretion. Amlodipine inhibits L-type calcium channels in vascular smooth muscle, reducing calcium influx and causing vasodilation. Together, they lower peripheral vascular resistance and blood pressure.

Indications

Hypertension (high blood pressure)

Side effects

Sleepiness Ankle swelling Headache Flushing sense of warmth in the face ears neck and trunk Dizziness Palpitations Increased potassium level in blood Fatigue Nausea Edema swelling Abdominal pain Visual disturbance Breathlessness Change in bowel habits Nasal congestion stuffy nose Upper respiratory tract infection

Pregnancy category

Losartan may cause fetal harm, especially in the second and third trimesters; avoid use in pregnancy. Amlodipine’s safety in pregnancy is not well established.

Precautions

Monitor blood pressure, renal function, serum potassium, signs of hypotension, angioedema, electrolyte imbalance, hepatic impairment, avoid abrupt withdrawal, caution in severe aortic stenosis, pregnancy, lactation, elderly, and patients with heart failure or volume depletion, assess for drug interactions.

Contraindications

Hypersensitivity to losartan, amlodipine, or excipients, pregnancy, severe hypotension, cardiogenic shock, severe aortic stenosis, unstable heart failure, history of angioedema with ARBs, severe hepatic impairment.