API

Ofloxacin (50mg/5ml)

Drug classification

Fluoroquinolone antibiotic; specifically, a second-generation fluoroquinolone.

Dosage form

Oral suspension containing ofloxacin 50 mg per 5 ml.

API strength per dosage

Dose

Oflox 50 Rediuse (ofloxacin 50mg/5ml) is typically used in children for susceptible infections; dosing is weight-based and should follow official guidelines. Adult dosing is not standard for this formulation. Dose adjustments are required in renal impairment; use with caution in hepatic dysfunction. Always consult product information and local protocols for specific recommendations.

Mechanism of action

Ofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination. This inhibition prevents supercoiling and separation of bacterial DNA, leading to impaired cell division and ultimately bacterial cell death.

Indications

Treatment of Bacterial infections

Side effects

Nausea Headache Dizziness Itching Insomnia difficulty in sleeping Rash Genital itching Vaginal inflammation Phlebitis Injection site reactions pain swelling redness

Pregnancy category

Ofloxacin should be avoided in pregnancy unless benefits outweigh risks; animal studies show fetal harm, and human data are limited. Consult a healthcare provider.

Precautions

Assess for hypersensitivity, history of tendon disorders, CNS disorders (seizures), renal impairment, risk of QT prolongation, photosensitivity, pediatric use caution, monitor for tendon pain/swelling, CNS effects, allergic reactions, liver and renal function, avoid with antacids or iron/zinc within 2 hours, ensure adequate hydration.

Contraindications

Hypersensitivity to ofloxacin or other quinolones, history of tendon disorders related to quinolone use, epilepsy, history of QT interval prolongation, children or adolescents during growth, pregnancy, breastfeeding.