API

Levocetirizine (5mg) + Phenylephrine (5mg) + Paracetamol (325mg)

Drug classification

Antihistamine (levocetirizine), decongestant (phenylephrine), and analgesic-antipyretic (paracetamol) combination.

Dosage form

Film-coated tablet for oral administration.

API strength per dosage

Dose

Okacet Cold Total Tablet is typically taken by adults and children over 12 years as directed by a physician, usually one tablet every 12 hours. Use in children under 12, or in patients with renal or hepatic impairment, requires caution and medical supervision. Dose adjustments may be necessary in renal or hepatic dysfunction. Always follow medical advice.

Mechanism of action

Levocetirizine selectively blocks peripheral H1 histamine receptors, reducing allergy symptoms. Phenylephrine is an alpha-1 adrenergic receptor agonist, causing vasoconstriction in nasal mucosa, relieving congestion. Paracetamol inhibits central prostaglandin synthesis via COX enzymes, providing analgesic and antipyretic effects. Together, they alleviate allergic rhinitis symptoms, nasal congestion, pain, and fever.

Indications

Treatment of Common cold

Side effects

Vomiting Dryness in mouth Headache Sleepiness Fatigue Constipation Diarrhea

Pregnancy category

Safety in pregnancy is not well established; use only if clearly needed and benefits outweigh potential risks. Consult a healthcare professional before use.

Precautions

Avoid in severe hypertension, severe coronary artery disease, severe hepatic or renal impairment, monitor blood pressure, monitor for CNS effects (drowsiness, dizziness), caution in elderly, avoid alcohol, assess for allergic reactions, monitor liver function with prolonged use, avoid concurrent MAO inhibitors, use with caution in pregnancy.

Contraindications

Hypersensitivity to levocetirizine, cetirizine, phenylephrine, paracetamol, or excipients; severe renal impairment; severe hypertension; severe coronary artery disease; narrow-angle glaucoma; concurrent use of MAO inhibitors; severe hepatic impairment.