API

Potassium Citrate (1080mg)

Drug classification

Potrate 10 is an electrolyte supplement; specifically, a urinary alkalinizer (potassium citrate).

Dosage form

Extended-release oral tablet containing potassium citrate 1080 mg.

API strength per dosage

Dose

Potrate 10 Tablet ER (Potassium Citrate 1080 mg) dosing is individualized based on urinary citrate and potassium levels. Typical adult doses start at 10–30 mEq two to three times daily with meals. Pediatric dosing is weight-based. Use cautiously in renal impairment; contraindicated in severe renal dysfunction. Monitor serum potassium regularly. Adjust dose to maintain target urinary citrate.

Mechanism of action

Potrate 10 (potassium citrate) dissociates to potassium and citrate ions. Citrate acts as an alkalinizing agent, buffering hydrogen ions and increasing urinary pH. This reduces urinary calcium crystallization by binding calcium, inhibiting stone formation, and enhancing citrate excretion, thereby preventing calcium oxalate and uric acid kidney stones.

Indications

Nutritional deficiencies

Side effects

Abdominal pain Vomiting Diarrhea Nausea

Pregnancy category

Potassium citrate should be used during pregnancy only if clearly needed; limited human data, but animal studies have not shown direct fetal harm.

Precautions

Renal impairment, hyperkalemia risk, cardiac disease, gastrointestinal ulceration or obstruction, monitor serum potassium, renal function, acid-base balance, avoid in severe renal insufficiency, use caution with potassium-sparing diuretics or ACE inhibitors, monitor for gastrointestinal symptoms, ensure adequate fluid intake, adjust dose based on laboratory values.

Contraindications

Hyperkalemia, chronic renal failure, severe renal impairment, untreated Addison’s disease, acute dehydration, heat cramps, peptic ulcer disease, active gastrointestinal bleeding, delayed gastric emptying, esophageal compression, hypersensitivity to potassium citrate or excipients.