API

Quetiapine (25mg)

Drug classification

Atypical antipsychotic; dibenzothiazepine derivative.

Dosage form

Quel 25mg Tablet is an oral tablet containing quetiapine 25mg.

API strength per dosage

Dose

Quetiapine dosing is individualized based on indication and patient factors. For adults, initial doses are typically low and titrated; elderly or hepatic impairment require lower starting doses and slower titration. Safety and efficacy in children vary by indication; consult specific guidelines. Dose adjustments may be needed in hepatic impairment. Always follow approved prescribing information.

Mechanism of action

Quetiapine antagonizes dopamine D2 and serotonin 5-HT2A receptors in the brain, reducing dopaminergic and serotonergic neurotransmission. It also blocks histamine H1 and adrenergic α1 and α2 receptors. This receptor antagonism leads to antipsychotic, mood-stabilizing, and sedative effects, improving symptoms of schizophrenia, bipolar disorder, and related conditions.

Indications

Treatment of SchizophreniaTreatment of Mania

Side effects

Dizziness Dryness in mouth Sleepiness Constipation Fatigue High blood pressure Orthostatic hypotension sudden lowering of blood pressure on standing Dyslipidemia

Pregnancy category

Quetiapine should be used during pregnancy only if benefits justify potential risks; limited human data, possible neonatal withdrawal or extrapyramidal symptoms reported. Consult physician.

Precautions

Monitor for sedation, orthostatic hypotension, metabolic changes (weight, glucose, lipids), extrapyramidal symptoms, tardive dyskinesia, neuroleptic malignant syndrome, QT prolongation, leukopenia, cataracts, seizure risk, hepatic impairment, elderly dementia-related psychosis risk, gradual withdrawal recommended, caution in cardiovascular disease, monitor for suicidality.

Contraindications

Hypersensitivity to quetiapine or excipients, concomitant use with CYP3A4 inhibitors, severe hepatic impairment, lactation, and caution in patients with a history of QT prolongation or uncontrolled cardiovascular disease.