API

Flucloxacillin Sodium (500mg)

Drug classification

Antibiotics (beta-lactam antibiotic, penicillinase-resistant penicillin)

Dosage form

Capsule

API strength per dosage

500 mg

Dose

Adults: 500 mg every 6 hours. Children 2–10 years: 250 mg every 6 hours. Children <2 years: 125 mg every 6 hours. Renal impairment: No routine dose adjustment; monitor for accumulation in severe impairment. Administer 30–60 minutes before meals.

Mechanism of action

Flucloxacillin inhibits bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBPs), particularly transpeptidases, preventing cross-linking of peptidoglycan chains. This weakens the cell wall, leading to osmotic instability and bacterial cell lysis. It is resistant to degradation by staphylococcal beta-lactamases.

Indications

Treatment of Bacterial infections

Side effects

Bloating Indigestion Gastrointestinal disturbance

Pregnancy category

Category B1

Precautions

History of allergy to penicillins or beta-lactams, hepatic dysfunction, renal impairment, monitor liver and renal function, monitor for hypersensitivity reactions, monitor for signs of superinfection, caution in elderly, monitor for gastrointestinal disturbances, assess for drug interactions, use in pregnancy and lactation only if clearly needed.

Contraindications

Hypersensitivity to flucloxacillin, other beta-lactam antibiotics (e.g., penicillins, cephalosporins), history of flucloxacillin-associated jaundice or hepatic dysfunction, serious allergic reactions to penicillins.