API

Liposomal Amphotericin B (50mg)

Drug classification

Antifungals (polyene antifungal, liposomal formulation).

Dosage form

Injection, liposomal suspension, 50 mg.

API strength per dosage

Dose

For systemic fungal infections, Liposomal Amphotericin B (Ambilon 50mg Injection) is typically dosed at 3-5 mg/kg/day for both adults and children. Dosage adjustments may be necessary for patients with renal impairment. Always consider patient-specific factors and monitor renal function during treatment.

Mechanism of action

Liposomal amphotericin B binds to ergosterol in fungal cell membranes, forming pores that increase membrane permeability, leading to cell contents leakage and fungal cell death.

Indications

Treatment of Severe fungal infectionsTreatment of Leishmaniasis.

Side effects

Decreased potassium level in blood Nausea Vomiting Chills Fever

Pregnancy category

Category B

Precautions

Contraindications