API

Methylcobalamin, Pregabalin, Folic Acid, Alpha Lipoic Acid, Pyridoxine

Drug classification

Methylcobalamin: Vitamin (Vitamin B12); Pregabalin: Anticonvulsant; Folic Acid: Vitamin. Combination: Neuropathic pain adjunct.

Dosage form

Capsule, Soft

API strength per dosage

Methylcobalamin 750mcg, Pregabalin 25mg, Folic…

Dose

Adults: 1 capsule once daily, swallowed whole with water. Safety and efficacy in pediatric patients have not been established. Use with caution in renal impairment; dose adjustment of pregabalin may be necessary. Not recommended in pregnancy or lactation unless clearly indicated.

Mechanism of action

Methylcobalamin acts as a cofactor for methionine synthase, facilitating homocysteine to methionine conversion. Pregabalin binds to the α2δ subunit of voltage-gated calcium channels, reducing neurotransmitter release. Folic acid is converted to tetrahydrofolate, essential for DNA synthesis and methylation reactions.

Indications

Peripheral neuropathy, diabetic neuropathy, neuropathic pain, vitamin B12 deficiency, folic acid deficiency, adjunct in epilepsy, fibromyalgia, generalized anxiety disorder.

Side effects

Pregnancy category

Category C

Precautions

Renal impairment, history of hypersensitivity, pregnancy and lactation, risk of dizziness or drowsiness, avoid alcohol, monitor for suicidal thoughts or mood changes, caution in elderly, potential drug interactions, avoid abrupt discontinuation, monitor for allergic reactions, use with caution in patients with cardiac disorders.

Contraindications