API

Cisplatin

Drug classification

Dosage form

Solution For Infusion

API strength per dosage

50 mg

Dose

Mechanism of action

Forms covalent bonds with purine DNA bases, primarily at the N7 position of guanine, causing intra- and inter-strand DNA crosslinks. This inhibits DNA replication and transcription, activates DNA damage response pathways (e.g., p53), and induces apoptosis in rapidly dividing cells.

Indications

Side effects

Nephrotoxicity, ototoxicity, myelosuppression, severe nausea and vomiting, peripheral neuropathy, electrolyte disturbances (hypomagnesemia, hypokalemia, hypocalcemia), anaphylactic reactions, hepatotoxicity, alopecia, tinnitus.

Pregnancy category

Precautions

Contraindications