API

Drug classification

Dosage form

Powder For Oral Suspension

API strength per dosage

AMOXYCILLIN 200MG AND CLAVULANIC ACID 28MG PER 5ML

Dose

Adults: Not typically used; tablets preferred. Pediatrics: 20–40 mg/kg/day amoxicillin (in divided doses every 8–12 hours) for mild/moderate infections; 40–60 mg/kg/day for severe infections. Renal impairment: Dose adjustment required. Hepatic impairment: Use with caution; monitor liver function.

Mechanism of action

Amoxicillin inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs), primarily transpeptidases. Clavulanic acid irreversibly inhibits bacterial β-lactamase enzymes, preventing amoxicillin degradation. This combination results in bactericidal activity against β-lactamase-producing and susceptible bacteria.

Indications

Acute otitis media, sinusitis, pharyngitis, tonsillitis, community-acquired pneumonia, bronchitis, urinary tract infections, skin and soft tissue infections, dental infections, bone and joint infections.

Side effects

Pregnancy category

Precautions

Contraindications