API

Drug classification

Dosage form

Tablet

API strength per dosage

500mcg

Dose

Adults: Acute gout flare, 1.2 mg at first sign of flare followed by 0.6 mg one hour later; maximum 1.8 mg over one hour. Prophylaxis, 0.6 mg once or twice daily. Pediatrics: Not recommended for children under 4 years. Adjust dose in renal or hepatic impairment.

Mechanism of action

Colchicine binds to tubulin, inhibiting its polymerization into microtubules, thereby disrupting cellular functions such as mitosis and neutrophil motility and activity, leading to reduced inflammation and pain in conditions like gout.

Indications

Side effects

Pregnancy category

Precautions

Contraindications