API

Drug classification

Dosage form

Tablet

API strength per dosage

500MG

Dose

Adults and children over 12 years: 500 mg to 1 g every 4 to 6 hours, maximum 4 g daily. Children 6-12 years: 250-500 mg every 4 to 6 hours, maximum 2 g daily. Adjust dose in hepatic impairment; contraindicated in severe hepatic dysfunction.

Mechanism of action

Paracetamol acts primarily by inhibiting the enzyme cyclooxygenase (COX), specifically COX-2 in the central nervous system, reducing prostaglandin synthesis, thereby decreasing pain perception and fever.

Indications

Side effects

Pregnancy category

Precautions

Avoid excessive use, monitor liver function with prolonged use, caution in patients with liver disease or alcohol dependence, adjust dose in renal impairment, avoid concurrent use with other paracetamol-containing products, consult healthcare provider before use if pregnant or breastfeeding, keep out of reach of children.

Contraindications