API

Dicycloverine Hydrochloride, Paracetamol

Drug classification

Dosage form

Tablet

API strength per dosage

Paracatamol B.P ...500mg Dicycloverine…

Dose

Adults: 1 tablet (Dicycloverine 20 mg + Paracetamol 500 mg) orally 2–3 times daily. Children (6–12 years): ½ tablet 2–3 times daily. Not recommended for children under 6 years. Use with caution in hepatic or renal impairment; dose adjustment may be necessary.

Mechanism of action

Dicycloverine hydrochloride antagonizes muscarinic acetylcholine receptors (primarily M3) on gastrointestinal smooth muscle, inhibiting cholinergic-mediated contractions. Paracetamol inhibits central cyclooxygenase (COX), particularly COX-2, reducing prostaglandin synthesis and thereby producing analgesic and antipyretic effects.

Indications

Abdominal pain, intestinal colic, dysmenorrhea, irritable bowel syndrome, spasmodic gastrointestinal disorders, biliary colic, renal colic.

Side effects

Dry mouth, dizziness, blurred vision, constipation, drowsiness, nausea, allergic reactions, skin rash, liver dysfunction, tachycardia, urinary retention, confusion, hypotension, abdominal pain.

Pregnancy category

Category B

Precautions

Contraindicated in glaucoma, myasthenia gravis, severe ulcerative colitis, obstructive uropathy, prostatic hypertrophy, hepatic or renal impairment, hypersensitivity to components, caution in elderly, avoid alcohol, risk of drowsiness, avoid in pregnancy and lactation unless necessary, monitor for anticholinergic side effects, do not exceed recommended dose.

Contraindications

Hypersensitivity to dicycloverine or paracetamol, obstructive uropathy, obstructive gastrointestinal disease, severe ulcerative colitis, myasthenia gravis, paralytic ileus, severe hepatic impairment, glaucoma.