API

Diosmin, Hesperidin.

Drug classification

Venotonic and vasculoprotective agent (Bioflavonoid complex).

Dosage form

Tablet

API strength per dosage

500 mg

Dose

For adults, the recommended dose of Daflon 500 mg is 1000 mg daily, typically divided into two doses of 500 mg each. There is insufficient data to recommend Daflon for pediatric use or specific dosing adjustments for special populations.

Mechanism of action

Daflon 500 mg enhances venous tone by modulating noradrenaline-induced venous contraction and increasing venous capacitance. It reduces capillary hyperpermeability and lymphatic drainage by protecting microcirculation from inflammatory processes, primarily through inhibition of P-selectin and leukocyte adhesion, thus alleviating edema and venous symptoms.

Indications

Chronic venous disease, symptomatic treatment of venous insufficiency, hemorrhoidal disease, acute hemorrhoidal attacks.

Side effects

Gastrointestinal disorders (e.g., diarrhea, dyspepsia, nausea), neurovegetative disorders (e.g., headache, malaise), cutaneous reactions (e.g., rash, pruritus), and isolated cases of facial, lip, eyelid angioedema.

Pregnancy category

Category C

Precautions

Avoid in hypersensitivity to flavonoids, use cautiously in renal or hepatic impairment, not recommended during pregnancy or breastfeeding, monitor for gastrointestinal side effects, interaction with other veno-active drugs, not a substitute for standard venous disease treatments, consult healthcare provider before combining with other supplements or medications.

Contraindications

Hypersensitivity to the active substance or any of the excipients, breastfeeding.