API

Tadalafil

Drug classification

Phosphodiesterase type 5 inhibitor (PDE5 inhibitor).

Dosage form

Tablet

API strength per dosage

Tadalafil 5mg per tablet

Dose

For adults, the recommended dose of Cialis (Tadalafil) 5 mg is once daily, taken at the same time each day, for the treatment of erectile dysfunction. Not recommended for use in pediatrics. Dosage adjustments may be necessary for patients with renal or hepatic impairment.

Mechanism of action

Tadalafil selectively inhibits phosphodiesterase type 5 (PDE5), an enzyme responsible for the breakdown of cyclic guanosine monophosphate (cGMP) in the smooth muscle cells lining the blood vessels supplying the corpus cavernosum of the penis. This inhibition enhances erectile function by increasing blood flow.

Indications

Erectile dysfunction, benign prostatic hyperplasia, pulmonary arterial hypertension.

Side effects

Pregnancy category

Precautions

Avoid use with nitrates, caution in cardiovascular disease, adjust dose in renal/hepatic impairment, not recommended post-recent myocardial infarction or stroke, potential for vision/hearing loss, may cause hypotension, not for women/children, interact with alpha-blockers, CYP3A4 inhibitors/inducers, assess for priapism risk, monitor for side effects like headache, dyspepsia.

Contraindications

Hypersensitivity to tadalafil, concurrent nitrate therapy, severe cardiac conditions, recent myocardial infarction, stroke, unstable angina, severe hepatic impairment, loss of vision due to NAION, hereditary degenerative retinal disorders.