API

Tadalafil

Drug classification

Dosage form

Tablet

API strength per dosage

Tadalafil 20mg per tablet

Dose

For erectile dysfunction in adults, the recommended dose of Tadalafil is 10 mg taken prior to anticipated sexual activity, with adjustments to 20 mg or reduced to 5 mg based on efficacy and tolerability. Not recommended for use in pediatrics. Adjust dose in patients with severe renal impairment.

Mechanism of action

Tadalafil inhibits phosphodiesterase type 5 (PDE5), an enzyme that degrades cyclic guanosine monophosphate (cGMP) in the corpus cavernosum. This inhibition enhances the effects of nitric oxide-induced cGMP, leading to increased blood flow and facilitating penile erection.

Indications

Erectile dysfunction, benign prostatic hyperplasia, pulmonary arterial hypertension.

Side effects

Pregnancy category

Precautions

Avoid use with nitrates, severe cardiovascular disorders, recent stroke or myocardial infarction, severe hepatic impairment, hypotension, renal impairment, predisposition to priapism, hereditary degenerative retinal disorders, concurrent use of alpha-blockers or antihypertensives, caution in peptic ulcer disease, anatomical penile deformation.

Contraindications

Hypersensitivity to tadalafil, concurrent nitrate therapy, severe cardiac conditions, recent myocardial infarction, stroke, unstable angina, uncontrolled hypertension, severe hepatic impairment, loss of vision due to NAION.