Topic overview

Start with the big picture

Fibronectin is a dimeric matrix protein whose RGD motif supports integrin binding and links cells with extracellular components. Produced by fibroblasts and hepatocytes, it can assemble into fibrils as mechanical forces expose sites that guide organization. Its functions include cell adhesion, migration, and wound healing. Laminin is a three-chain protein that forms networks in the basal lamina, binds other matrix components and integrins, and helps establish basement-membrane structure, filtration, and cell polarity. The lesson also introduces laminin-332’s role in keratinocyte anchorage and clinical associations involving laminin-chain mutations. Together, these proteins illustrate how matrix assembly and integrin signaling influence cell behavior, while glycosylation and protein fragments contribute to matrix interactions and responses to injury.