Clinical Pharmacy renal system

chronic renal failure

Topic overview

Start with the big picture

CKD is defined by a GFR below 60 mL/min/1.73 m² or evidence of kidney damage for at least three months. Diabetes and hypertension are leading causes; glomerulonephritis and polycystic kidney disease are also important. Classification combines GFR stages, from G1 through G5, with albuminuria categories. Management spans blood pressure control and therapies intended to slow progression, alongside care for anemia, mineral and bone disorder, acidosis, hyperkalemia, and volume overload. Pharmacy practice also requires attention to nephrotoxins, medicines that may be unsuitable at low eGFR, renal dose adjustment, and monitoring. The full lesson further addresses dialysis, immunizations, nutrition, patient counseling, and follow-up.

Learning objectives

What you'll learn

  • Define CKD using GFR and duration or evidence of kidney damage.
  • Identify common CKD etiologies and describe GFR and albuminuria classification.
  • Summarize major approaches to blood pressure control and slowing CKD progression.
  • Recognize key CKD complications and medication-safety considerations.
  • Explain why renal function assessment and monitoring inform medication dosing.
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