Topic overview

Start with the big picture

Diagnosis begins with nontreponemal screening tests such as RPR or VDRL, followed by confirmation with treponemal assays such as FTA-ABS or TP-PA. Management depends on the stage and clinical presentation: early and late latent disease, neurosyphilis, ocular or otic involvement, and congenital infection have distinct treatment considerations. The lesson also addresses penicillin allergy and pregnancy, when penicillin remains the recommended therapy and desensitization is advised for allergy. Follow-up includes serologic monitoring, recognition of the Jarisch–Herxheimer reaction, and assessment for treatment failure or reinfection. Correct formulation, partner management, sexual-health counseling, and public-health reporting are also important parts of care.