Clinical Pharmacy CNS disorders

pain

Topic overview

Start with the big picture

Pain classification helps guide whether treatment should focus on tissue injury, nerve dysfunction, or both. The WHO analgesic ladder offers a framework for stepwise escalation, while medication selection requires attention to safety, monitoring, and patient-specific risks. The lesson reviews acetaminophen, NSAIDs, COX-2 inhibitors, and opioids, including opioid initiation, adverse effects, and overdose-risk mitigation. It also introduces first-line medication groups for neuropathic pain and topical options for localized relief. Special sections address migraine therapies, spasticity-related pain, acute inflammatory flares, multimodal analgesia, and patient-controlled analgesia. These are introductory concepts; individual treatment decisions require clinical judgment and consideration of the patient’s circumstances.

Learning objectives

What you'll learn

  • Distinguish nociceptive, neuropathic, and mixed pain and relate classification to therapy selection.
  • Describe the stepwise structure of the WHO analgesic ladder.
  • Identify major safety considerations for acetaminophen, NSAIDs, COX-2 inhibitors, and opioids.
  • Summarize medication approaches to neuropathic pain and localized symptoms.
  • Recognize the lesson’s coverage of migraine, spasticity-related pain, and multimodal strategies.
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