Topic overview

Start with the big picture

Drug-induced injury may result from direct toxicity at higher doses or from individual susceptibility, including immune-mediated and metabolic factors. Examples span several organ systems: acetaminophen can cause centrilobular hepatic necrosis when glutathione is depleted, while some medicines are associated with hepatic fibrosis or cholestasis. Cardiac, pulmonary, and renal effects include cardiomyopathy, interstitial fibrosis, and acute kidney injury. Blood and skin reactions include aplastic anemia, agranulocytosis, and severe epidermal reactions. The deeper lesson organizes these toxicities by injury pattern and organ system, connecting representative drugs with mechanisms and clinical manifestations. This preview provides an orientation; it is not a substitute for the broader topic coverage.