Human Pathology Cardiovascular Pathology

Valvular Heart Diseases

Topic overview

Start with the big picture

Aortic stenosis obstructs left ventricular outflow and produces pressure overload, while aortic regurgitation causes volume overload; their findings reflect these different stresses. Mitral stenosis is commonly rheumatic and may lead to left atrial enlargement and pulmonary hypertension. Mitral regurgitation and prolapse have distinct murmur patterns and potential complications. The overview also covers tricuspid and pulmonic valve disease, rheumatic valve changes, and infective endocarditis. Across these conditions, recognizing the lesion’s cause, characteristic examination findings, and effects on cardiac chambers helps organize the topic and understand its clinical consequences.

Learning objectives

What you'll learn

  • Distinguish major causes and structural features of aortic stenosis and regurgitation.
  • Relate valve lesions to characteristic murmurs and hemodynamic effects.
  • Identify key features and complications of mitral stenosis, regurgitation, and prolapse.
  • Describe selected findings in tricuspid and pulmonic valve disease.
  • Recognize the roles of rheumatic heart disease and infective endocarditis in valve pathology.
Ready for the complete lesson?

Continue your study

Work through the complete notes and reinforce the topic with the study tools available in the full lesson.

PharmaProLearn

Excel Beyond Limits