Human Pathology Respiratory Pathology

Lung Cancer: Types and Prognosis

Topic overview

Start with the big picture

NSCLC accounts for most lung cancers and includes adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. These subtypes differ in typical location, associated features, and reported outcomes. SCLC is a neuroendocrine tumor marked by rapid growth and early dissemination; carcinoid tumors generally have a more favorable prognosis, with outcomes varying by grade. Prognosis is not determined by histology alone: TNM stage is a key predictor in NSCLC, while performance status, weight loss, comorbidities, metastases, and relevant molecular targets also matter. The deeper lesson compares these patterns and places survival figures in context, including the distinction between limited and extensive SCLC.

Learning objectives

What you'll learn

  • Distinguish NSCLC, SCLC, and carcinoid tumors by broad biological features.
  • Identify key features of the principal NSCLC subtypes.
  • Compare prognosis across lung cancer types and stages.
  • Describe clinical and molecular factors that influence prognosis.
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