Human Pathology Gastrointestinal Pathology

Esophageal Disorders: GERD, Barrett's Esophagus

Topic overview

Start with the big picture

GERD is chronic reflux of gastric contents that causes troublesome symptoms or complications. The source describes contributing mechanisms such as reduced lower esophageal sphincter tone, transient sphincter relaxation, hiatal hernia, and delayed gastric emptying. Heartburn and regurgitation are typical; dysphagia, weight loss, and gastrointestinal bleeding are alarm signs that prompt endoscopic evaluation. Management progresses from lifestyle measures to medication and, in selected cases, procedural options. Barrett’s esophagus is intestinal metaplasia in the distal esophagus, confirmed by biopsy after characteristic endoscopic findings. Its significance lies in the dysplasia progression pathway toward adenocarcinoma, making surveillance and management important parts of the topic.

Learning objectives

What you'll learn

  • Explain mechanisms that increase esophageal acid exposure in GERD.
  • Distinguish typical GERD symptoms from alarm signs.
  • Describe the diagnostic features of Barrett’s esophagus.
  • Summarize the progression from Barrett’s metaplasia through dysplasia.
  • Outline the source’s GERD treatment hierarchy and Barrett’s surveillance approach.
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