Topic overview

Start with the big picture

The lesson surveys statins, fibrates, bile-acid sequestrants, niacin, ezetimibe, PCSK9 inhibitors, omega-3 ethyl esters, and bempedoic acid. It highlights how structural features relate to drug action, including the statin dihydroxyheptanoic acid core and ezetimibe’s azetidinone structure, and contrasts targets such as HMG-CoA reductase, PPAR-α, NPC1L1, and PCSK9. The material also reviews effects on LDL, triglycerides, and HDL alongside metabolism and notable adverse effects. Topic headings indicate further coverage of lomitapide, mipomersen, experimental CETP inhibitors, and combination therapy, followed by a visual mechanism summary and comparative table.